Lauren W. Stranahan

Coxiella burnetii type IVB secretion system modulates TLR3/TRIF-dependent NF-κB and IRF responses during infection

This study shows Coxiella burnetii uses its type IVB secretion system to suppress TLR3/TRIF signaling, inhibiting NF-κB and IRF responses during infection.

Mycobacterium tuberculosis manipulates host inflammation and lipid metabolism through the SET1-interacting protein Rv1075c

This study identifies Rv1075c as a Mycobacterium tuberculosis nucleomodulin that interacts with the SET1 histone methyltransferase complex, modulating host inflammation and lipid metabolism to promote bacterial persistence.

Mitochondrial STAT3-mediated suppression of apoptosis constrains antimycobacterial immunity

This study identifies Trim14's role in suppressing apoptosis via mitochondrial Stat3 during Mtb infection, enhancing antimycobacterial immunity.

Necrosis drives susceptibility to Mycobacterium tuberculosis in PolgD257A mutator mice

This study shows that mtDNA mutations in PolgD257A mice increase susceptibility to Mtb by impairing innate immunity and promoting necrosis.