Age and IFN-β-induced changes in glial morphometry can be captured by in vivo diffusion-weighted magnetic resonance spectroscopy.
Eva Periche-Tomas, Itamar Ronen, Jonathan Underwood, John Evans, Claire MacIver, Helena Leach, Francesca Branzoli, Mara Cercignani, Neil Andrew Harrison
This study uses dMRS to show IFN-β increases thalamic tCho diffusivity and age is linked to lower tNAA diffusivity and higher tCho/tCr in white matter.
bioRxiv · Mar 26, 2026 · PreprintImmunology