Simon A. Jones

This study shows inflammatory arthritis disrupts the blood-retinal barrier and promotes T cell recruitment to the eye, increasing susceptibility to uveitis without causing overt ocular disease.

This paper develops IFN-β as a safe in-vivo model of human inflammation, inducing robust sickness responses with minimal cardiovascular effects in healthy volunteers aged 18-75.

This study characterizes the lipid composition of SARS-CoV-2 envelopes from cultured strains and patient isolates, showing inflammation-induced changes and identifying lipid targets for antiviral and antithrombotic strategies.

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

Alox15-deficient mice heal skin punch wounds with excess collagen, low matrix metalloproteinase activity and unresolved inflammatory gene expression; topical physiological 12/15-lipoxygenase oxylipin mixtures reduced collagen and raised collagenase activity.

This study identifies IL-6's role in elevating thrombosis in RA via platelet 12-lipoxygenase-generated pro-coagulant phospholipids.

The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.