BiochemistryNature CommunicationsPeer-reviewed
Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα
Daniel J. Boesch, Nadia I Martin, Chantal A Kontor…·Tyler Weaver
This study investigates how DNA Ligase IIIα ligates nicks in nucleosomes using biochemical assays, molecular dynamics, and cryo-EM, revealing position-dependent efficiency and structural constraints.