Emmanuelle Bignon

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

This study investigates how DNA Ligase IIIα ligates nicks in nucleosomes using biochemical assays, molecular dynamics, and cryo-EM, revealing position-dependent efficiency and structural constraints.

Structural basis of the two-photon photoactivation mechanism of orange carotenoid protein

The paper elucidates the structural basis of the two-photon photoactivation mechanism of orange carotenoid protein using a combination of structural and biochemical methods.

InterMap: Accelerated Detection of Interaction Fingerprints on Large-Scale Molecular Ensembles

InterMap accelerates interaction fingerprint detection in large molecular ensembles, achieving significant reductions in runtime and memory usage compared to existing tools.

DynaRepo: The repository of macromolecular conformational dynamics

DynaRepo provides a repository of macromolecular conformational dynamics with simulations and analyses for over 450 complexes and 270 proteins.

Specific binding modes of SIRT6 C-terminal domain to the nucleosome core particle influence DNA unwrapping and H3K27 accessibility

This study uses molecular dynamics simulations to investigate how the C-terminal domain of SIRT6 interacts with the nucleosome, influencing DNA unwrapping and H3K27 accessibility.

Structure, dynamics, and processing of 8oxoG:A in the nucleosome

This study determines the structure and dynamics of 8oxoG:C and 8oxoG:A base pairs in the nucleosome and characterizes MUTYH activity, revealing that 8oxoG:A is less processable by MUTYH.

Communication pathway analysis within protein-nucleic acid complexes

The paper introduces ComPASS, a computational method to analyze communication networks in protein-nucleic acid complexes, revealing distinct signal transmission mechanisms across various systems.

Histone H3 cysteines as redox switches in the nucleosome: molecular modeling of S-sulfenylation and its structural consequences

This study investigates how oxidation of histone H3 cysteines affects nucleosome structure using molecular modeling, revealing mechanisms and structural consequences of S-sulfenylation.

Molecular bases and specificity behind the activation of the immune system OAS/RNAse L pathway by viral RNA.

This study uses molecular dynamics simulations to investigate how viral RNA activates the OAS/RNase L immune pathway by altering OAS conformation and free energy profiles.

Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

This study reveals how SIRT6 binds to nucleosomes to position its active site for efficient histone H3 deacetylation.