Yu Liu

The paper identifies a DNA-histone methylation axis that drives KMT2A amplifications and rearrangements in leukemia, revealing therapeutic targets.

The paper integrates epigenomic features to identify chromatin-state classes and shows Polycomb-associated chromatin drives cell-type-specific differences.

This study shows histone hyperacetylation disrupts TAD intra-interactions but preserves CTCF-CTCF loops, revealing distinct cohesin populations with different sensitivity to acetylation.

This study shows that cohesin residence time, not just its presence, determines how histone hyperacetylation affects 3D genome structure.

The paper shows mitotic chromosomes are self-entangled and disentangle through a Topoisomerase II-dependent two-stage process during mitotic exit.

This study identifies biochemically distinct cohesin complexes that mediate different types of chromatin loops based on genomic context.

The paper uses multi-contact 3C data to show that chromosomes and compartment domains in the human genome are largely unentangled.

This study identifies hsa-mir-210 as a prognostic marker for lung squamous cell carcinoma through differential expression and survival analysis of miRNAs from TCGA and GEO datasets.

The paper identifies a RAD21 variant in a family with sclerocornea, showing it cosegregates with the disease and reduces RAD21 cleavage.

The paper shows CTCF binding and nucleosome positioning at CTCF sites change during the cell cycle, with loss of binding in prometaphase and rearrangement of chromatin structure.

The paper develops Tri-C, a single-cell 3C method, to reveal dynamic chromatin interactions and regulatory hubs in mammalian cells.