Lennart Lenk

clinTALL: machine learning-driven multimodal subtypeclassification and treatment outcome prediction in pediatric T-ALL

clinTALL is a deep learning framework that classifies pediatric T-ALL subtypes and predicts treatment outcomes using multimodal data, achieving high accuracy and concordance indices.

Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups

This study identifies how developmental maturity and fusion partner influence treatment response in KMT2A-rearranged B-ALL across all ages.

A novel Fc-optimized antibody drug conjugate targeting CD7 for the therapy of T-cell acute lymphoblastic leukemia

This paper evaluates a novel Fc-optimized antibody drug conjugate targeting CD7, showing potent anti-leukemia activity in preclinical T-ALL models.