Lorenz Bastian

The paper demonstrates that ovarian cancer organoids derived from mesonephric-like adenocarcinoma can be used for functional precision medicine, showing sensitivity to binimetinib and resistance to standard chemotherapeutics.

The paper introduces ALLCatchR2, a machine learning classifier that identifies 20 T-ALL subtypes across multiple cohorts and age groups with high accuracy.

IntegrateALL is an RNA-seq pipeline that integrates expression-based subtyping, gene fusion detection, and virtual karyotyping to classify B-ALL with high accuracy.

This study identifies how developmental maturity and fusion partner influence treatment response in KMT2A-rearranged B-ALL across all ages.

RoCK and ROI improves single-cell transcriptomics by targeting specific transcripts and regions, enhancing detection of critical biological features.

This study evaluates the efficacy of CD38 and CD20 IgG1/IgA2 antibodies in mediating myeloid cell-mediated killing of B-ALL, showing enhanced activity with CD47/SIRPα blockade.