Claudia Dorothea Baldus

The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groups

The paper introduces ALLCatchR2, a machine learning classifier that identifies 20 T-ALL subtypes across multiple cohorts and age groups with high accuracy.

IntegrateALL: an end-to-end RNA-seq analysis pipeline for multilevel data extraction and interpretable subtype classification in B-precursor ALL

IntegrateALL is an RNA-seq pipeline that integrates expression-based subtyping, gene fusion detection, and virtual karyotyping to classify B-ALL with high accuracy.

Blinatumomab-driven T-cell activation in αβ and γδ T-cell subsets: Insights from in vitro assays

This study evaluates BLN-driven cytotoxicity in β and γδ T-cell subsets, finding β T cells show superior cytotoxicity while γδ T cells exhibit stable effector-memory states and reduced susceptibility to activation-induced cell death.

Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups

This study identifies how developmental maturity and fusion partner influence treatment response in KMT2A-rearranged B-ALL across all ages.

A Novel Natural Killer Cell Expansion Technology for the Development of Cellular Immunotherapies

This paper introduces a multifunctional fusion protein that enables efficient ex vivo expansion of NK cells from various sources and enhances their cytotoxic activity against tumor cells.

RoCK and ROI: Single-cell transcriptomics with multiplexed enrichment of selected transcripts and region-specific sequencing

RoCK and ROI improves single-cell transcriptomics by targeting specific transcripts and regions, enhancing detection of critical biological features.

A novel Fc-optimized antibody drug conjugate targeting CD7 for the therapy of T-cell acute lymphoblastic leukemia

This paper evaluates a novel Fc-optimized antibody drug conjugate targeting CD7, showing potent anti-leukemia activity in preclinical T-ALL models.

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist

The paper develops patient-derived AML PDX models that replicate primary AML biology and include subgroups lacking existing models, showing reduced leukemia growth after long-term chemotherapy.

Myeloid cell-mediated killing of B-ALL by CD38 and CD20IgA antibody variants is enhanced by CD47/SIRPα interference

This study evaluates the efficacy of CD38 and CD20 IgG1/IgA2 antibodies in mediating myeloid cell-mediated killing of B-ALL, showing enhanced activity with CD47/SIRPα blockade.

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.