Anja Lux

An unbiased map of FcγR signaling in neutrophils reveals druggable nodes in immune complex-mediated autoimmune disease

The paper identifies BTK as a therapeutic target in antibody-mediated autoimmune diseases by mapping FcγR signaling in neutrophils using kinase inhibitors and disease models.

CDK7, CDK9, or CDK11 Inhibition Reduces Neutrophil-Driven Inflammation and Tissue Damage in Experimental Autoimmune Models

A human immune system mouse model for preclinical evaluation of therapies in pemphigoid disease

This study develops a human immune system mouse model for EBA, demonstrating that PDK1 inhibition reduces skin inflammation and immune cell activation.

ERK5 is required for neutrophil-mediated ROS release and essential in epidermolysis bullosa acquisita

This study shows ERK5 inhibition reduces neutrophil ROS release and ameliorates EBA, suggesting ERK5 as a therapeutic target in ROS-driven autoimmune diseases.

A novel Fc-optimized antibody drug conjugate targeting CD7 for the therapy of T-cell acute lymphoblastic leukemia

This paper evaluates a novel Fc-optimized antibody drug conjugate targeting CD7, showing potent anti-leukemia activity in preclinical T-ALL models.