Julia Falo Sanjuan

Direct observation of Notch signalling induced transcription hubs mediating gene-expression responses

The paper shows Notch signaling forms transcription hubs that regulate gene expression by correlating hub dynamics with transcription profiles.

Targeted mutagenesis of specific genomic DNA sequences in animals for the in vivo generation of variant libraries

The paper develops a method to generate variant libraries in vivo using base editing to study gene regulatory programs in multicellular organisms.

Levels of Notch-regulated transcription are modulated by tissue movements at gastrulation

The paper shows that gastrulation movements in Drosophila increase Notch-responsive enhancer activity, suggesting mechanical forces influence transcription levels.

Membrane architecture and adherens junctions contribute to strong Notch pathway activation

The paper shows that adherens junctions enhance Notch pathway activation during Drosophila embryonic cellularization by facilitating membrane contact formation.

Enhancer priming enables fast and sustained transcriptional responses to Notch signaling

The paper shows how enhancers decode Notch signaling by altering transcription burst duration and requiring priming by transcription factors for sustained activity.

In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer

This study develops a dual-color fluorescent transcriptional timer to monitor spatio-temporal gene expression dynamics in Drosophila, identifying new genes with dynamic expression patterns.

Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signalling

The paper shows that the Mi-2/NuRD complex suppresses Notch signaling in Drosophila neural stem cell progeny, preventing excessive stem cell proliferation and hyperplasia.