Abnormal AMPAR-mediated synaptic plasticity, cognitive and autistic-like behaviors in a missense Fmr1 mutant mouse model of Fragile X syndrome
Marta Prieto, Alessandra Folci, Gwénola Poupon, Sara Schiavi, Valeria Buzzelli, Marie Pronot, Urielle François, Paula A. Pousinha, Norma Lattuada, Sophie Abélanet, Sara Castagnola, Magda Chafaï, Anouar Khayachi, Carole Gwizdek, Frédéric Brau, , Stéphane Martin
This study investigates a missense Fmr1 mutation in mice, showing increased spine density, synaptic defects, and cognitive deficits linked to Fragile X syndrome.
Nature Communications · Mar 10, 2021Peer-reviewedNeuroscience