Paula A. Pousinha

AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.

This study identifies AETA peptide as a novel contributor to synaptic dysfunction in Alzheimer's disease, particularly in females, through post-mortem analysis and a mouse model.

Reinforced Hippocampus-Accumbens pathway marks a shift towards cognitive decline in aging

The paper identifies age-related changes in the hippocampus-accumbens pathway in mice and links them to cognitive decline, showing that reducing pathway excitability can improve memory.

Age-dependent NMDA receptor function is regulated by the Amyloid Precursor Protein

This study identifies APP's role in regulating NMDAR function during development and aging, showing distinct mechanisms in postnatal and aged stages.

Abnormal AMPAR-mediated synaptic plasticity, cognitive and autistic-like behaviors in a missense Fmr1 mutant mouse model of Fragile X syndrome

This study investigates a missense Fmr1 mutation in mice, showing increased spine density, synaptic defects, and cognitive deficits linked to Fragile X syndrome.

Disrupting D2-NMDA receptor heteromerization blocks the rewarding effects of cocaine but preserves natural reward processing

The paper shows disrupting D2-NMDA receptor heteromerization blocks cocaine's rewarding effects without affecting natural reward processing in mice and humans.

Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

This study shows that FTY720 treatment after symptom onset in an AD mouse model improves synaptic and memory deficits through anti-inflammatory effects.