Author

Don Ashley O. Malabana

Saint Louis UniversityORCID 0000-0002-3925-7714Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew Huy NguyeniD· 1 shared Ankan Kumar BhadraiD· 1 shared Denise M. SmithiD· 1 shared Geetika AggarwaliD· 1 shared Jathin Kollarapu· 1 shared Joel Jihwan HwangiD· 1 shared Nitya NagarajaniD· 1 shared Subhashis BanerjeeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

Andrew Huy NguyenORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintOct 13, 2026

Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome

Geetika Aggarwal, Subhashis Banerjee, Ankan Kumar Bhadra…·Andrew Huy Nguyen

This study shows that progranulin deficiency increases NLRP3 inflammasome activity via cathepsin B, leading to neuroinflammation, and demonstrates that ASO treatment can reverse this effect in GRN-deficient cells.

DOI 10.64898/2026.10.11.758389

mousehuman

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