Author

Joel Jihwan Hwang

Saint Louis UniversityORCID 0009-0002-5296-7267Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew Huy NguyeniD· 1 shared Ankan Kumar BhadraiD· 1 shared Denise M. SmithiD· 1 shared Don Ashley O. MalabanaiD· 1 shared Geetika AggarwaliD· 1 shared Jathin Kollarapu· 1 shared Nitya NagarajaniD· 1 shared Subhashis BanerjeeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

Andrew Huy NguyenORCID

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1 paper

Recent·Most cited

Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome

Geetika Aggarwal, Subhashis Banerjee, Ankan Kumar Bhadra, Joel Jihwan Hwang, Don Ashley O. Malabana, Nitya Nagarajan, Denise M. Smith, Jathin Kollarapu, Andrew Huy Nguyen

This study shows that progranulin deficiency increases NLRP3 inflammasome activity via cathepsin B, leading to neuroinflammation, and demonstrates that ASO treatment can reverse this effect in GRN-deficient cells.

bioRxiv · Oct 13, 2026 · PreprintNeuroscience