Giovanni González-Gutiérrez

Self-S-sulfonation in a bacterial persulfide dioxygenase mediates thiol persulfide detoxification

This paper identifies a self-S-sulfonation mechanism in bacterial persulfide dioxygenase CstB that converts thiol persulfides to thiosulfate without sulfite release.

Extracellular Vacuole-derived bodies (EVacs) mediate RNA secretion in plants

The paper identifies EVacs as vacuole-derived structures that mediate RNA secretion in plants by encapsulating and releasing cytoplasmic RNA and proteins into the apoplast.

Evolution of allostery without shape shifting: Internal dynamics drives functional diversification of a transcriptional repressor superfamily

The paper investigates how allostery evolves in the ArsR superfamily by showing that functional diversification arises from internal dynamics rather than large conformational changes.

A Fragment Screen Identifies Acrylamide Covalent Inhibitors of the TEAD/YAP Protein-Protein Interaction

The paper identifies acrylamide fragments that covalently inhibit TEAD4-YAP interaction by reacting with a conserved cysteine in the TEAD palmitate pocket.

CH···S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter

The paper identifies alkyl CH···S hydrogen bonds as critical for molecular recognition of ergothioneine by the microbial transporter EgtUC.

Dual DNA-binding capability of Cdc13 coordinates with Ku to safeguard telomere integrity

This study shows that Cdc13's dual DNA-binding capability coordinates with Ku to protect telomeres, and mutations in this function lead to metabolic reprogramming and increased fitness in yeast.

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation

This study investigates how the ratio of nucleic acid to SARS-CoV-2 N-protein affects liquid-liquid phase separation (LLPS) and finds that a 1:1 ratio maximizes condensate formation.