BiochemistrybioRxivPreprint
A Fragment Screen Identifies Acrylamide Covalent Inhibitors of the TEAD/YAP Protein-Protein Interaction
Khuchtumur Bum‐Erdene, Mona K. Ghozayel, Mark J. Zhang…·Samy O. Meroueh
The paper identifies acrylamide fragments that covalently inhibit TEAD4-YAP interaction by reacting with a conserved cysteine in the TEAD palmitate pocket.
DOI 10.64898/2026.03.18.712694