Sergei Y. Sokol

Axin2L regulates planar cell polarity in Xenopus embryos

This study shows Axin2L regulates planar cell polarity in Xenopus embryos by interacting with ADIP and affecting Vangl2 and ciliogenesis.

R-spondin2 regulates planar cell polarity in the vertebrate neural plate

This study identifies R-spondin2 as a modulator of planar cell polarity in the Xenopus neural plate, showing it maintains Vangl2 asymmetry and limits its phosphorylation.

Planar polarization of endogenous ADIP during Xenopus neurulation

This study shows endogenous ADIP polarizes in response to mechanical forces during Xenopus neurulation, linking it to cytoskeletal networks and planar cell polarity.

Force-dependent stabilization of apical actomyosin by Lmo7 during vertebrate neurulation

This study shows Lmo7 stabilizes actomyosin at the apical cortex during neural tube closure through force-dependent binding to NMII, enhancing apical constriction.

FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation

This study shows FGFR1 modulates PCP in the neuroectoderm by phosphorylating Vangl2, disrupting its interaction with Prickle and PTK7.

Mechanosensitive localization of Diversin highlights its function in vertebrate morphogenesis and planar cell polarity

This study shows Diversin localizes to cell junctions during Xenopus morphogenesis and responds to mechanical forces, influencing planar cell polarity and tissue closure.

Mechanical cues organize planar cell polarity during vertebrate morphogenesis and embryonic wound repair

The paper shows that ADIP and Diversin form a mechanosensitive complex involved in planar cell polarity during morphogenesis and wound repair in Xenopus embryos.

Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation

This study shows that Prickle2 enhances tissue fluidity during vertebrate neurulation by remodeling apical junctions, facilitating neural tube formation.

Mechanical control of neural plate folding by apical domain alteration

The paper investigates how apical domain alterations in Xenopus neural plate cells drive tissue folding through mechanical interactions and PCP signaling.

Myocardin-related transcription factors regulate morphogenetic events in vertebrate embryos by controlling F-actin organization and apical constriction

This study shows that Mrtf proteins regulate apical constriction and morphogenetic events in Xenopus embryos by controlling F-actin organization.

Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate

This study shows that Frizzled3 inhibits Vangl2-Prickle3 association in Xenopus neural plate cells, regulating planar cell polarity through phosphorylation.

The dorsal blastopore lip is a source of signals inducing PCP in the Xenopus neural plate

The paper shows that the dorsal blastopore lip provides a planar signal inducing PCP in the Xenopus neural plate, distinct from neural inducers and not dependent on graft orientation.

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

This study shows Rspo2 inhibits TCF3 phosphorylation to block Wnt signaling during Xenopus anteroposterior axis development.

Pinhead antagonizes Admp to promote notochord formation

This study identifies Pnhd as a protein that binds and inhibits Admp, reducing Smad1 phosphorylation and promoting notochord formation in Xenopus embryos.