Alpha-synuclein oligomers activate nuclear factor of activated T-cells (NFAT) modulating apoptosis and synaptic homeostasis
Ricardo Sant’Anna, Bruno Kaufmann Robbs, Júlia Araújo de Freitas, Patrícia I. Santos, Annekatrin König, Tiago F. Outeiro, Débora Foguel
The paper shows that alpha-synuclein oligomers activate NFAT, leading to neuronal toxicity and synaptic loss, which can be reversed by NFAT inhibitors.
bioRxiv · Feb 21, 2023 · PreprintNeuroscience