Patrícia I. Santos

This study overexpresses human alpha-synuclein in rodent glutamatergic neurons and finds no significant impairment in synaptic function.

This study models aSyn assemblies in living cells and shows that Sph1-aSyn interactions influence inclusion formation, morphology, and localization, providing insights into protein aggregation and potential therapeutic strategies.

The paper shows that alpha-synuclein oligomers activate NFAT, leading to neuronal toxicity and synaptic loss, which can be reversed by NFAT inhibitors.

This study uses super-resolution microscopy to examine the molecular structure of alpha-synuclein inclusions in cell models and human brain tissue, revealing conserved patterns and shapes.