The paper develops a 3D imaging method to identify the Periportal Lamellar Complex (PLC) as a structural regulator of liver ductal and neuronal branching.

eLife · Apr 22, 2026Peer-reviewedCell Biology

Multi-Omics Reveals Activated Fibroblasts with Dual Functional Roles in Repair and Negative Barrier in the CD8+ T Cell Cytotoxic Niche for Lung Cancer Neoadjuvant Therapy

Ruihan Zhou, Chaoxin Xiao, Ping Zhou, Ouying Yan, Banglei Yin, Xiaohong Yao, Jiaxin Liu, Xuexue Wu, WW Hou, Yulin Wang, Huanhuan Wang, Rui Zhu, Zirui Wang, Leyi Yao, Xiaoying Li, , Chengjian Zhao

The paper introduces NICHE, a multi-omics framework to analyze immune niches in lung cancer, revealing fibroblasts with dual roles in tissue repair and immunosuppression.

bioRxiv · Jan 15, 2026 · PreprintImmunology

Pipeline for Assessing Tumor Immune Status Using Superplex Immunostaining and Spatial Immune Interaction Analysis

Chaoxin Xiao, Ruihan Zhou, Qin Chen, Wanting Hou, Xiaoying Li, Yulin Wang, Lu Liu, Huanhuan Wang, Xiaohong Yao, Tongtong Xu, Fujun Cao, Banglei Yin, Ouying Yan, Lili Jiang, Wei Wang, , Chengjian Zhao

This paper introduces a high-throughput superplex staining platform and a computer vision pipeline to analyze spatial immune interactions in tumor microenvironments.

bioRxiv · Aug 23, 2024 · PreprintCancer Biology