In vivo deuteration reveals pronounced variation in myelin lipid turnover rates and reduced myelin renewal with ageing
Jun Yup Lee, Yushan Cai, Mika T. Westerhausen, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Georgia Watt, Shane R. Ellis, Anthony Simon Don
This study uses in vivo deuteration and lipidomics to show that myelin lipid turnover varies by lipid class and brain region, with reduced renewal rates in older mice.
bioRxiv · Feb 19, 2026 · PreprintBiochemistry