Jonathan D. Teo

This study quantifies and localizes new myelin lipid synthesis in mice using deuterium oxide and mass spectrometry during remyelination.

This study uses in vivo deuteration and lipidomics to show that myelin lipid turnover varies by lipid class and brain region, with reduced renewal rates in older mice.

This study shows that mice lacking CerS2 in oligodendrocytes develop myelin instability, microglial activation, and early lethality due to reduced C22-C24 sphingolipids.

This study shows that SphK2 is essential for remyelination after demyelination and myelin maintenance with age, as SphK2 deficiency leads to greater oligodendrocyte loss and thinner myelin.