Author

Holly P. McEwen

The University of SydneyORCID 0000-0002-8233-1553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Anthony Simon DoniD· 2 shared Huitong Song· 2 shared Jonathan D. TeoiD· 2 shared Abdul MannaniD· 1 shared Alanna Gabrielle SpiteriiD· 1 shared Alicia M. DouglasiD· 1 shared Andrew H. WeiiD· 1 shared Anjie GeiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Anthony Simon DonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Adaptive resistance to FLT3 inhibitors is potentiated by ROS-driven DNA repair signalling

Dilana Elisabeth Staudt, Zacary P. Germon, Abdul Mannan, Tabitha McLachlan, Heather C. Murray, Ryan J. Duchatel, Bryce C. Thomas, Tyrone S. Beitaki, Holly P. McEwen, Mika L. Persson, Leah Calvert, Izac J. Findlay, Evangeline R. Jackson, Nathan D. Smith, David Anthony Skerrett-Byrne, , Matthew D. Dun

This study identifies ATM-driven DNA repair and ROS addiction as mechanisms of resistance to FLT3 inhibitors in AML and shows ATM inhibition can overcome resistance in vitro and in vivo.

bioRxiv · Jul 26, 2024 · PreprintCancer Biology

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

Jonathan D. Teo, Oana C. Marian, Alanna Gabrielle Spiteri, Madeline Nicholson, Huitong Song, Jasmine X. Y. Khor, Holly P. McEwen, Anjie Ge, Monokesh Kumer Sen, Laura M. Piccio, Jessica L. Fletcher, Nicholas J. C. King, Simon S. Murray, Jens C. Brüning, Anthony Simon Don

This study shows that mice lacking CerS2 in oligodendrocytes develop myelin instability, microglial activation, and early lethality due to reduced C22-C24 sphingolipids.

Glia · Dec 30, 2022Peer-reviewedNeuroscience

Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication

Huitong Song, Holly P. McEwen, Thomas Duncan, Jun Yup Lee, Jonathan D. Teo, Anthony Simon Don

This study shows that SphK2 is essential for remyelination after demyelination and myelin maintenance with age, as SphK2 deficiency leads to greater oligodendrocyte loss and thinner myelin.

Glia · Aug 16, 2021Peer-reviewedNeuroscience