Shane R. Ellis

STILL-13C maps lipid metabolic flux in intact human tissues using isotopic labeling and MSI, revealing spatial heterogeneity in lipid pathways and responses to inhibition.

This study characterizes the dynamic lipidome changes in human neutrophils during NETosis and identifies phospholipid lipase networks as key regulators.

This study creates a spatial ganglioside atlas for mouse and human brains using mass spectrometry imaging, revealing species-specific distributions and differences between species and brain regions.

This study quantifies and localizes new myelin lipid synthesis in mice using deuterium oxide and mass spectrometry during remyelination.

This study uses in vivo deuteration and lipidomics to show that myelin lipid turnover varies by lipid class and brain region, with reduced renewal rates in older mice.

This paper introduces MIMA, a deep learning framework for multi-omics integration and batch correction, which effectively removes batch effects and preserves biological information across modalities.

This paper introduces a subcellular mass spectrometry imaging technique that enhances lipid and nucleotide detection using transmission geometry ambient laser desorption and plasma ionisation.

An open-source cloud engine annotates imaging mass spectrometry data at controlled false discovery rate; publicly shared results reached over 3200 datasets and 6 million metabolite images by January 2019.