Author

Adriaan Vanderstichele

Universitair Ziekenhuis LeuvenORCID 0000-0002-3984-2948Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Research Focus:batch correction / integration· 1 Organism:human· 1 Approach:optimal transport· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

An CoosemansiD· 2 shared Diether LambrechtsiD· 2 shared Dirk TimmermaniD· 2 shared Joris Robert VermeeschiD· 2 shared Tatjana JatsenkoiD· 2 shared Agnieszka WoźniakiD· 1 shared Antoine PassemiersiD· 1 shared Antonia Carla TestaiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioinformatics

An CoosemansORCID

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2 papers

Recent·Most cited

Alleviating cell-free DNA sequencing biases with optimal transport

Antoine Passemiers, Tatjana Jatsenko, Adriaan Vanderstichele, Pieter Busschaert, An Coosemans, Dirk Timmerman, Diether Lambrechts, Daniele Raimondi, Joris Robert Vermeesch, Yves Moreau

This paper introduces an optimal transport-based domain adaptation method to correct technical biases in cfDNA sequencing data, improving cancer detection and enabling cohort integration.

bioRxiv · Apr 4, 2024 · PreprintBioinformatics

Pan-cancer detection and typing by mining patterns in large genome-wide cell-free DNA sequencing datasets

Huiwen Che, Tatjana Jatsenko, Liesbeth Lenaerts, Luc Dehaspe, Leen Vancoillie, Nathalie Brison, Ilse Parijs, Kris Van Den Bogaert, D. Fischerová, Ruben Heremans, Chiara Landolfo, Antonia Carla Testa, Adriaan Vanderstichele, Lore Liekens, Valentina Pomella, , Joris Robert Vermeesch

The paper develops a method to detect and type cancer using cfDNA sequencing data, achieving 81.62% accuracy in distinguishing malignant from control samples.

Clinical Chemistry · Jun 29, 2022Peer-reviewedGenetic & Genomic Medicine