Dirk Timmerman

Single-cell dissection of cervix and placenta reveal both novel and overlapping cell types

The paper uses single-cell RNA-sequencing to analyze cervical and placental tissues, identifying a novel trophoblast subtype and revealing similarities between maternal epithelial cells and placental trophoblasts.

MetDecode: methylation-based deconvolution of cell-free DNA for non-invasive multi-cancer typing

MetDecode uses methylation patterns to estimate tumor proportion and identify tissue origin in cell-free DNA samples from cancer patients.

Alleviating cell-free DNA sequencing biases with optimal transport

This paper introduces an optimal transport-based domain adaptation method to correct technical biases in cfDNA sequencing data, improving cancer detection and enabling cohort integration.

Pan-cancer detection and typing by mining patterns in large genome-wide cell-free DNA sequencing datasets

The paper develops a method to detect and type cancer using cfDNA sequencing data, achieving 81.62% accuracy in distinguishing malignant from control samples.