Diether Lambrechts

This study benchmarks multiple sequencing-based spatial transcriptomics platforms across tissue types and preservation methods to evaluate their performance and establish standardized metrics for future research.

This study introduces TWISTAR, a platform to identify tumor-reactive TCRs and their antigens, revealing shared immunogenic targets across cancers and immune dominance.

PRANA adapts polygenic risk scores to non-European populations, improving predictive accuracy by 5%-20% in South Asian, East Asian, and Ashkenazi Jewish populations.

This study identifies three distinct tumor immune microenvironment (TIME) subtypes in glioblastoma (GBM) with divergent responses to immunotherapy, supporting personalized treatment strategies.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

This paper introduces an optimal transport-based domain adaptation method to correct technical biases in cfDNA sequencing data, improving cancer detection and enabling cohort integration.

This study examines differences in polygenic risk score distributions across European populations and shows how country-specific calibration can improve breast cancer risk prediction.

The paper identifies genetic markers for anthracycline-induced cardiotoxicity risk by analyzing intermediate molecular phenotypes in mice and human cohorts.

Combining pseudobulk differential expression, cell-type specificity, sample prevalence and NicheNet-v2 ligand activity, MultiNicheNet ranks condition-specific ligand-receptor-target signaling in multi-sample scRNA-seq with batches or multifactor designs.

The paper develops a method to detect and type cancer using cfDNA sequencing data, achieving 81.62% accuracy in distinguishing malignant from control samples.

This study shows that FTO affects m6A marking on SARS-CoV-2 RNA and correlates with COVID-19 severity in patients.

The paper characterizes the activated stem cell phenotype in the neonatal mouse pituitary, revealing its regenerative capacity and distinct molecular features compared to adult pituitary.

The paper analyzes rare copy number variants (CNVs) in breast cancer cases and controls, identifying associations with known and novel susceptibility loci.

The paper shows DNA methylation prevents HIF binding, affecting hypoxia responses and tumour immunotolerance.

This study uses single-cell profiling of bronchoalveolar lavages to compare immune responses in mild and critical COVID-19, identifying differences in T-cell function and macrophage differentiation that correlate with disease severity.

This study combines genome-wide association data from four cancers to identify shared and novel genetic associations and pleiotropic effects.