Allen Yen

This study shows that norepinephrine modulates synapses via astrocytic adrenergic receptors and Ca2+ dynamics, independent of neuronal receptors.

The paper shows that epigenetic variation recorded in mice during development predicts seizure susceptibility, with specific loci linked to human epilepsy genes.

This study examines the role of MYT1L in neuronal development by analyzing gene expression in wild-type and MYT1L-deficient mice, finding disruptions in excitatory neuron proportions and gene expression.

Calling Cards records protein-DNA interactions over time using transposons, enabling analysis of historical molecular states through sequencing.

This study examines functional connectivity changes in Mecp2 knockout mice, finding disrupted connectivity in males and subtle changes in females, suggesting sex-specific roles of MeCP2 in circuit development.

This paper introduces barcoded self-reporting transposon calling cards to efficiently measure transcription factor binding and gene expression in bulk populations, demonstrating their use in vitro and in vivo.