NeurosciencebioRxivPreprint
Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory
Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Dhruba Pathak…·Tsuneya Ikezu
This study shows that tau propagation from entorhinal cortex to hippocampal CA1 neurons leads to sex-specific cognitive and electrophysiological impairments, driven by distinct neuroimmune responses in males and females.
DOI 10.64898/2026.02.19.706636