Jean-Christophe Delpech

This paper introduces a microfluidic device for detecting and sorting single fluorescent extracellular vesicles, demonstrating its utility for downstream analysis and biomarker enrichment.

This study shows that Atg18a regulates exosome release and rescues pathogenic dysfunction caused by a Parkinson's disease mutation in Synaptojanin.

This study shows that tau propagation from entorhinal cortex to hippocampal CA1 neurons leads to sex-specific cognitive and electrophysiological impairments, driven by distinct neuroimmune responses in males and females.

The paper presents a standardized workflow for multi-omic profiling of brain and plasma-derived EVs from minimal human and mouse material, revealing tissue-specific and species-specific molecular signatures.

This study shows that inhibiting CSF1R in male MIA offspring improves sociability and memory, while female offspring show no improvement, highlighting sex-specific therapeutic potential.

The paper shows that amyloid plaques accelerate tau propagation in mice by activating microglia, which secrete more extracellular vesicles.

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.