23S rRNA modifications stimulate catalytic activity and prevent the formation of alternative structures
Daniel S. D. Larsson, Aivar Liiv, Rya Ero, Jaanus Rèmme, M. Selmer
This study shows that 23S rRNA modifications enhance ribosome catalytic activity by stabilizing the peptidyl transferase center structure and preventing alternative conformations.
Nucleic Acids Research · Aug 3, 2026Peer-reviewedMolecular Biology