Daniel S. D. Larsson

This study shows that 23S rRNA modifications enhance ribosome catalytic activity by stabilizing the peptidyl transferase center structure and preventing alternative conformations.

The paper shows that HrpA-dependent ribosome collision processing recruits tmRNA and Hsp15 to resolve stalled ribosomes in E. coli under antibiotic treatment.

The paper shows that E. coli tRNASer3 can induce -1 frameshifting on GCA codons through doublet-decoding, revealing a mechanism involving A1493 and U36 interactions.

The paper elucidates how FusB rescues protein synthesis from fusidic acid inhibition by altering EF-G conformation and facilitating its dissociation from the ribosome.

The paper presents cryo-EM structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and its derivative FA-cyclopentane, revealing binding interactions and structural details relevant to drug discovery.

The paper uses cryo-EM to characterize LiCl core particles of E. coli 50S ribosomes, revealing structural similarities between disassembly and assembly processes and insights into RNA-protein interactions.