M. Selmer

23S rRNA modifications stimulate catalytic activity and prevent the formation of alternative structures

This study shows that 23S rRNA modifications enhance ribosome catalytic activity by stabilizing the peptidyl transferase center structure and preventing alternative conformations.

Structural characterization of ribosome recycling and fusidic acid inhibition in Staphylococcus aureus

The paper uses cryo-EM to characterize ribosome recycling and fusidic acid inhibition in Staphylococcus aureus, revealing structural insights into the mechanism of antibiotic action.

Ribosome collisions trigger tmRNA-mediated rescue through mRNA disengagement

The paper shows that HrpA-dependent ribosome collision processing recruits tmRNA and Hsp15 to resolve stalled ribosomes in E. coli under antibiotic treatment.

Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center

The paper shows that E. coli tRNASer3 can induce -1 frameshifting on GCA codons through doublet-decoding, revealing a mechanism involving A1493 and U36 interactions.

Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis

The paper elucidates how FusB rescues protein synthesis from fusidic acid inhibition by altering EF-G conformation and facilitating its dissociation from the ribosome.

Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane

The paper presents cryo-EM structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and its derivative FA-cyclopentane, revealing binding interactions and structural details relevant to drug discovery.

Cryo-EM reconstructions of LiCl core particles show strong similarities between disassembly and assembly of the ribosomal 50S subunit

The paper uses cryo-EM to characterize LiCl core particles of E. coli 50S ribosomes, revealing structural similarities between disassembly and assembly processes and insights into RNA-protein interactions.