Philippa Clare Matthews

Pan-genotypic probe-based enrichment to improve efficiency of Hepatitis B virus sequencing

This paper introduces a pan-genotypic probe-based enrichment method to enhance HBV sequencing efficiency, showing significant increases in HBV read counts and viral load correlation.

Polymorphisms Predicting Phylogeny in Hepatitis B Virus (HBV)

This study uses random forest analysis to identify amino acid sites in HBV genome that predict genotype, finding 10 key sites across four genes with implications for HBV evolution and spacer domain function.

Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission

Illumina and Nanopore methods for whole genome sequencing of hepatitis B virus (HBV)

This paper describes a method to generate full-length HBV genome data using isothermal amplification and sequencing with Nanopore and Illumina, achieving high consensus accuracy and resolving intra-sample variants.

Detection of viral pathogens with multiplex Nanopore MinION sequencing: be careful with cross-talk

The paper assesses cross-talk in multiplex Nanopore MinION sequencing and finds 0.056% of reads are misassigned due to chimeric reads.