Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to virus escape
JOHN CLARKE, Luke M. Jones, Imogen Buckle…·Raymond J. Owens
This study identifies two potent nanobodies targeting the conserved S2 region of SARS-CoV-2 spike protein that resist viral escape and reduce viral load in a hamster model.