Joseph P. Mizgerd

This study identifies Oncostatin M (OSM) as a critical regulator of pulmonary host responses during influenza and bacterial pneumonia, revealing non-canonical signaling pathways.

The paper defines sub-phenotypes of pneumonia using histopathological features from human lung samples and validates them in mouse models.

This study observes a mosaic pattern of aerosol distribution in alveoli across species and ages, revealing functional heterogeneity in lung deposition and its implications for disease and therapy.

This study identifies pathogen-specific neutrophil surface protein phenotypes in bacterial pneumonia, revealing tissue- and infection-type dependent immune responses.

This study identifies lung CD4+ resident memory T cells and their interaction with airway secretory cells as key regulators of neutrophilic allergic airways disease in mice and humans.

The paper shows that neutrophils in a murine pneumococcal pneumonia model transition through two distinct transcriptional trajectories with associated metabolic changes.