Author

Connor Purcell

Brown UniversityORCID 0000-0002-4060-4277Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Maximilian P. Pinho-SchwermanniD· 3 shared Wafik S. El‐DeiryiD· 3 shared Elizabeth C. Ding· 2 shared Praveen R. SrinivasaniD· 2 shared Shengliang ZhangiD· 2 shared William J. MacDonaldiD· 2 shared Jillian StrandbergiD· 1 shared Vida TajikniaiD· 1 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

8 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

Maximilian P. Pinho-SchwermannORCID

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3 papers

Recent·Most cited

Neuroendocrine differentiation (ND) in sensitivity of neuroendocrine tumor (NET) cells to ONC201/TIC10 cancer therapeutic

Elizabeth C. Ding, Maximilian P. Pinho-Schwermann, Shengliang Zhang, Connor Purcell, Wafik S. El‐Deiry

This study shows that ONC201 is effective against prostate cancer and small cell lung carcinoma cells, regardless of neuroendocrine differentiation markers or BRN2 overexpression.

bioRxiv · Aug 28, 2024 · PreprintCancer Biology

ITGB6 inhibition stimulates anti-tumor responses in immunocompetent mouse models of head & neck squamous cell carcinoma and pancreatic adenocarcinoma

William J. MacDonald, Praveen R. Srinivasan, Maximilian P. Pinho-Schwermann, Shengliang Zhang, Vida Tajiknia, Connor Purcell, Jillian Strandberg, Wafik S. El‐Deiry

This study shows that inhibiting ITGB6 enhances anti-tumor immune responses in mouse models of head and neck and pancreatic cancers, with potential for combination immunotherapy.

bioRxiv · Apr 18, 2024 · PreprintCancer Biology

Neuroendocrine Prostate Cancer Drivers SOX2 and BRN2 Confer Differential Responses to Imipridones ONC201, ONC206, and ONC212 in Prostate Cancer Cell Lines

Connor Purcell, Praveen R. Srinivasan, Maximilian P. Pinho-Schwermann, William MacDonald, Elizabeth C. Ding, Wafik S. El‐Deiry

This study investigates whether neuroendocrine differentiation (NED) affects sensitivity to imipridones ONC201 and ONC206 in prostate cancer cell lines, finding differential responses based on SOX2 and BRN2 overexpression.

American Journal of Translational Research · Jan 1, 2024Peer-reviewedCancer Biology