Author

William J. MacDonald

Brown UniversityORCID 0009-0000-5507-7839Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Connor PurcelliD· 2 shared Maximilian P. Pinho-SchwermanniD· 2 shared Praveen R. SrinivasaniD· 2 shared Wafik S. El‐DeiryiD· 2 shared Elizabeth C. Ding· 1 shared Jillian StrandbergiD· 1 shared Shengliang ZhangiD· 1 shared Vida TajikniaiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Connor PurcellORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 18, 2024

ITGB6 inhibition stimulates anti-tumor responses in immunocompetent mouse models of head & neck squamous cell carcinoma and pancreatic adenocarcinoma

William J. MacDonald, Praveen R. Srinivasan, Maximilian P. Pinho-Schwermann…·Wafik S. El‐Deiry

This study shows that inhibiting ITGB6 enhances anti-tumor immune responses in mouse models of head and neck and pancreatic cancers, with potential for combination immunotherapy.

DOI 10.1101/2024.04.18.590156

mousebulk RNA-seq

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Cancer BiologyAmerican Journal of Translational ResearchPeer-reviewedJan 1, 2024

Neuroendocrine Prostate Cancer Drivers SOX2 and BRN2 Confer Differential Responses to Imipridones ONC201, ONC206, and ONC212 in Prostate Cancer Cell Lines

Connor Purcell, Praveen R. Srinivasan, Maximilian P. Pinho-Schwermann…·Wafik S. El‐Deiry

This study investigates whether neuroendocrine differentiation (NED) affects sensitivity to imipridones ONC201 and ONC206 in prostate cancer cell lines, finding differential responses based on SOX2 and BRN2 overexpression.

4 citations

humanproteomics

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