Matthias Kirschner

Longitudinal White Matter Microstructure and Transition to Psychosis in Individuals at Clinical High Risk

The paper examines the relationship between white matter microstructure, measured by fractional anisotropy, and transition to psychosis in individuals at clinical high risk, finding directionally consistent but small associations.

HippoGenes: A robust workflow for subregional transcriptomic profiling of the human hippocampus

HippoGenes creates transcriptomic maps of the human hippocampus using spatial statistical models and the Allen Human Brain Atlas, enabling subregional gene expression analysis and disease-related molecular decoding.

Longitudinal White Matter Trajectories in Clinical High Risk and First-Episode Psychosis: Findings from the Multi-Centre PSYSCAN Study

The paper examines longitudinal white matter changes in early psychosis using diffusion tensor imaging and finds no significant group differences or associations with symptom progression, but links antipsychotic medication dose to lower fractional anisotropy.

Bridging Glucose Metabolism and Intrinsic Functional Organization of the Human Cortex

This study links intrinsic functional brain organization to energy expenditure patterns, showing that functional connectivity dimensions explain significant variance in metabolic maps.

Neuroanatomical Correlates of Negative Symptoms in Schizophrenia

This study identifies small but consistent anatomical correlates of negative symptom dimensions in schizophrenia, linking them to prefrontal cortical thickness and limbic subcortical volumes.

Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations

This study identifies neurodevelopmentally rooted epicenters of cortical thickness alterations in schizophrenia, linking them to specific functional regions and genetic factors.

Associations between epilepsy-related polygenic risk and brain morphology in childhood

The paper examines associations between epilepsy-related polygenic risk scores and brain morphology in children, finding PRS-related cortical thinning linked to structural patterns in TLE-HS patients.

Multimodal neural correlates of childhood psychopathology

The paper identifies multimodal brain network patterns associated with dimensions of psychopathology using the Adolescent Brain Cognitive Development dataset.

Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-Biobank

This study links genetic risk for schizophrenia with retinal thinning using UK Biobank data, highlighting neuroinflammatory pathways as a potential mechanism.

HippoMaps: Multiscale cartography of the human hippocampal formation

HippoMaps provides a toolbox and data warehouse for mapping and analyzing hippocampal data across multiple modalities and scales.

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

The paper identifies a shared cortical morphology dimension across six psychiatric conditions using MRI data from 28,546 participants.

Comparing adaptive coding of reward in bipolar I disorder and schizophrenia

The paper compares adaptive coding of reward in bipolar I disorder and schizophrenia, finding similar deficits in the right posterior caudate but more preserved coding in BD in anterior regions.

Schizophrenia polygenic risk during typical development reflects multiscale cortical organization

This study links schizophrenia polygenic risk to cortical thickness changes in developing children, showing a trajectory toward adult schizophrenia patterns.

Cerebellar and cortico-striatal-midbrain contributions to reward-cognition processes and apathy within the psychosis continuum

The paper investigates neural correlates of reward-cognition interactions and apathy in the psychosis continuum using fMRI and clinical scores.

The ENIGMA Toolbox: Cross-disorder integration and multiscale neural contextualization of multisite neuroimaging datasets

The paper introduces the ENIGMA Toolbox, a Python/Matlab ecosystem for integrating multisite neuroimaging datasets across disorders and contextualizing findings at multiple scales.

Determinants of Real-Time fMRI Neurofeedback Performance and Improvement: a Machine Learning Mega-Analysis

This study uses machine learning to analyze 608 participants and identifies two factors improving neurofeedback performance: pre-training no-feedback runs and training patients over healthy participants.

Can we predict real-time fMRI neurofeedback learning success from pre-training brain activity?

This study investigates whether pre-training brain activity can predict success in real-time fMRI neurofeedback learning across 24 studies and 401 participants, finding a weak correlation but no consistent predictors.

Individual differences in successful self-regulation of the dopaminergicmidbrain

This study examines how individual differences in self-regulation of the dopaminergic midbrain relate to cognitive control and reward sensitivity during neurofeedback training.

Spatial patterning of tissue volume loss in schizophrenia reflects brain network architecture

This study links tissue volume loss in schizophrenia to structural and functional connectivity, finding that 25-35% of regional deformation variance is explained by these factors.

Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia

This study compares apathy and reward system dysfunction in bipolar I disorder and schizophrenia, finding comparable apathy severity but distinct neural correlates.

Self-regulation of the Dopaminergic Reward Circuit in Cocaine Users with Mental Imagery and Neurofeedback

This study shows that cocaine users can self-regulate their reward system using non-drug imagery and that real-time fMRI neurofeedback enhances this ability.