Qiyong Gong

Charting sex divergence in the human brain across the lifespan

This paper constructs sex-specific lifespan brain charts using neuroimaging data from 59,915 individuals, revealing dynamic sex differences in brain development and improving detection of neuropsychiatric abnormalities.

Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories

The paper develops population-specific brain charts for Chinese individuals, revealing distinct neurodevelopmental patterns compared to Western populations and showing better performance in predicting brain phenotypes.

Subgenual Anterior Cingulate Cortex Functional Connectivity Abnormalities in Depression: Insights from Brain Imaging Big Data and Precision-Guided Personalized Intervention via Transcranial Magnetic Stimulation

The paper identifies sgACC functional connectivity abnormalities in depression using large-scale brain imaging data and develops an individualized TMS targeting algorithm to improve treatment outcomes.

Functional connectome through the human life span

The paper analyzes functional and structural MRI data from 33,250 individuals to map lifespan changes in the functional connectome, identifying key developmental stages and differences in neurological disorders.

Multivalent Targeting of Blood-Brain Barrier LRP1 for Neurovascular Recovery Therapy for Alzheimer s Disease

This study develops a multivalent scaffold targeting LRP1 at the BBB to reduce Aβ deposits and cognitive decline in AD model mice.

A neural signature for the subjective experience of threat anticipation under uncertainty

The paper develops a neural signature that predicts anxious arousal during uncertain threat anticipation using fMRI and multivariate modeling.

Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome

The paper identifies two neurophysiological subtypes of MDD using normative models of functional connectivity in a large multisite fMRI dataset.

Connectome Gradient Dysfunction in Major Depression and Its Association with Gene Expression Profiles

This study identifies dysfunction in the principal connectome gradient in MDD and links it to gene expression profiles related to transsynaptic signaling and calcium ion binding.

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

The paper analyzes resting-state fMRI data from 1,300 MDD patients and 1,128 controls to find reduced default mode network functional connectivity in recurrent MDD, not first-episode MDD.

Reproducibility of functional brain alterations in major depressive disorder: evidence from a multisite resting-state functional MRI study with 1,434 individuals

This study investigates reproducibility of functional brain alterations in MDD using a large multisite R-fMRI dataset and finds consistent patterns across centers but notes influences from clinical factors.