An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in Cryptococcus neoformans
Jun T. Huang, Connor J. Larmore, Timothy C. Davenport…·Joseph Heitman
This study identifies a mycovirus, CnTV1, that persists in RNAi-deficient Cryptococcus neoformans isolates due to a NUMT insertion disrupting Ago1, and shows RNAi is critical for viral control.