Sheng Sun

This study shows that tunicamycin from Streptomyces induces unisexual reproduction in Cryptococcus species through meiotic processes and developmental reprogramming.

This study identifies a mycovirus, CnTV1, that persists in RNAi-deficient Cryptococcus neoformans isolates due to a NUMT insertion disrupting Ago1, and shows RNAi is critical for viral control.

The paper identifies essential transcriptional regulators in Cryptococcus neoformans, highlighting Ezt1 as a key regulator of growth, drug response, and virulence.

This study identifies three hybrid groups in Cryptococcus neoformans with genomic features indicative of parasexual reproduction, including LOH, aneuploidy, and haploid recombinants.

This study identifies meiosis-specific genes critical for ploidy reduction in Cryptococcus neoformans titan cells, showing their role in generating stable diploid daughter cells.

This study investigates the role of HD genes in sexual reproduction and demonstrates a tetrapolar-to-bipolar transition in Cryptococcus amylolentus using CRISPR-Cas9 gene editing.

This study identifies Sxi1's inhibitory role in unisexual cell fusion and distinct transcriptional regulation from Sxi2a in Cryptococcus deneoformans.

This paper analyzes whole-genome sequences of Cryptococcus deneoformans to find evidence of both a- and - sexual reproduction and recombination in natural populations.

This study shows that mutating the RIC8 gene in Cryptococcus neoformans enables unisexual reproduction involving meiotic recombination, suggesting it may be more common in nature than previously thought.

The paper traces the evolution of mating-type loci in Cryptococcus and related species, revealing genomic dynamics like locus expansions, GC-content changes, and linkage transitions.

This study shows that STRIPAK complex defects in Cryptococcus neoformans lead to pseudosexual reproduction, affecting genome stability and inheritance.

This study identifies essential genes in the mating-type locus of Cryptococcus neoformans, showing that four genes are essential for viability while MYO2 is critical for pathogenicity despite not being essential.

This paper investigates the role of the STRIPAK complex in Cryptococcus neoformans, showing it regulates genome stability, sexual development, and virulence through functional characterization of its subunits.

The paper identifies RNAi loss-of-function mutations in Cryptococcus neoformans and shows they can lead to hypermutation when combined with transposon burdens.

The paper compares the genomes of pathogenic and non-pathogenic Cryptococcus species with related Kwoniella species, revealing gene gains/losses and chromosome fusion mechanisms linked to pathogenesis.

The paper shows calcineurin regulates RNAi-mediated transgene silencing and small RNA production in Cryptococcus neoformans through P-body localization and substrate interactions.

The paper tests the accidental pathogen hypothesis by identifying a QTL linked to amoeba resistance and melanization in Cryptococcus species, finding no correlation with macrophage resistance or virulence.

This study identifies genetic interactions governing morphogenesis in Cryptococcus fungi using QTL analysis, revealing epistatic relationships between genes involved in signaling pathways.

This study tracks genomic changes in serially passaged Cryptococcus neoformans x deneoformans hybrids, revealing patterns of mutation, LOH, and aneuploidy associated with adaptation.

This paper identifies genetic loci and pathways underlying virulence traits in Cryptococcus deneoformans using QTL mapping and finds that key signaling pathways contribute to phenotypic variation.

The paper investigates whether loss of the mismatch repair protein Msh2 relaxes species boundaries between Cryptococcus neoformans and C. deneoformans, finding increased hybrid viability and aneuploidy but no increased recombination.

This study shows that centromere scission in Cryptococcus neoformans leads to chromosome translocations, reproductive isolation, and speciation-like effects without altering gene sequences.

The paper identifies centromere regions in Malassezia species and shows that centromere loss drives karyotype evolution by causing chromosome breakage and fusion.

This study identifies the pheromone and pheromone receptor mating-type locus as controlling mitochondrial uniparental inheritance in Cryptococcus species.

The paper isolates and genetically analyzes Cryptococcus neoformans from olive trees in Turkey, revealing a novel niche and geographic distribution patterns of fungal lineages.

The paper maps meiotic recombination in Cryptococcus deneoformans, finding lower recombination rates in unisexual reproduction compared to bisexual crosses.

This study uses population genomics to explore how environmental selective pressures shaped virulence traits in Cryptococcus neoformans, identifying genetic differences between clinical and environmental isolates.