Author

Connor J. Larmore

Duke Medical CenterORCID 0000-0002-5341-7788Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Joseph HeitmaniD· 2 shared Jun T. HuangiD· 2 shared Sheng SuniD· 2 shared Anna Floyd AveretteiD· 1 shared Artem BabaianiD· 1 shared Fred S. Dietrich· 1 shared Humberto DebatiD· 1 shared Marc D. MeneghiniiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenetics

Joseph HeitmanORCID

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2 papers

Recent·Most cited

An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in Cryptococcus neoformans

Jun T. Huang, Connor J. Larmore, Timothy C. Davenport, Anna Floyd Averette, Yeseul Choi, Humberto Debat, P. P. Gupta, Artem Babaian, Marc D. Meneghini, Sheng Sun, Joseph Heitman

This study identifies a mycovirus, CnTV1, that persists in RNAi-deficient Cryptococcus neoformans isolates due to a NUMT insertion disrupting Ago1, and shows RNAi is critical for viral control.

bioRxiv · Sep 17, 2026 · PreprintGenetics

Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans

Jun T. Huang, Connor J. Larmore, Shelby J. Priest, Ziyan Zoe Xu, Fred S. Dietrich, Vikas Yadav, Paul M. Magwene, Sheng Sun, Joseph Heitman

The paper identifies RNAi loss-of-function mutations in Cryptococcus neoformans and shows they can lead to hypermutation when combined with transposon burdens.

Proceedings of the National Academy of Sciences · Nov 13, 2024Peer-reviewedGenetics