Lactobacillus Restructures the Micro/Mycobiome to Combat Glycoprotein-130 Associated Microtubule Remodeling and Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
Sasha Z. Prisco, Madelyn Blake, Felipe Kazmirczak, Ryan A. Moon, Benjamin P. Kremer, Lynn M. Hartweck, Minwoo Kim, Neal T. Vogel, Jenna B. Mendelson, Daphne Moutsoglou, Thenappan Thenappan, Kurt W. Prins
This study shows Lactobacillus modulates the gut microbiome to reduce inflammation and improve RV function in PAH by counteracting GP130-mediated microtubule remodeling.
Circulation Heart Failure · May 16, 2025Peer-reviewedPhysiology