Olaf Ansorge

This paper introduces ARMS DNAseq, a scalable spatial genomic assay that maps copy number subclones in archival tissue, revealing tumor evolution and subclone associations with morphology and transcriptomic features.

This study identifies the synaptic targets and cellular sources of CB1 and VGLUT3-expressing nerve terminals in the human cerebral cortex, showing their interactions with GABAergic neurons.

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

The paper identifies rare somatic mutations in sporadic ALS and FTD cases, suggesting they contribute to disease and widespread neurodegeneration.

The paper introduces an automated pipeline for registering stand-alone histology sections to whole-brain MRI data with sub-voxel accuracy.

This paper performs a large meta-analysis of GWAS in dementia with Lewy bodies, identifying sex-specific genetic risk signals and highlighting the need for larger cohorts.

This paper introduces an automated pipeline to extract quantitative histological metrics for voxelwise MRI-histology comparisons and finds activated microglia strongly predicts DTI FA, suggesting diffusion MRI sensitivity to neuroinflammation.

The paper investigates how group III mGluR activation affects GABAergic synaptic transmission in two types of human neocortical interneurons, finding differential effects on inhibitory currents.

The paper introduces the Digital Brain Bank, an open access platform providing curated post-mortem neuroimaging datasets across species and modalities for neuroanatomical and neuropathological research.

This paper develops a Kinetic Tensor model to correct T2 inhomogeneity in post-mortem brain imaging by accounting for fixative outflux, showing improved alignment with histological markers.

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.

This paper proposes using two-flip angle DW-SSFP data and a Gamma distribution model to correct for B1 inhomogeneity and improve diffusivity estimates in post-mortem human brains at 7T.

The paper describes a pipeline for quantitative susceptibility and R2* mapping in post-mortem brains and compares results between ALS patients and controls using histology validation.

The paper introduces a pipeline for automatically aligning histological images with whole-brain MRI data, achieving sub-millimetre accuracy and outperforming manual methods.

This study investigates white matter degeneration in the perforant path of ALS patients using diffusion MRI, polarized light imaging, and immunohistochemistry, finding significant changes in fractional anisotropy and myelin density.

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

The paper assesses benign genetic variability in elderly individuals without neurodegenerative disease to aid in distinguishing pathogenic mutations.