David Watson

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

The paper identifies seven sex-dependent differentially methylated positions in ALS blood samples, suggesting sex-specific biological mechanisms in the disease.

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

M3C: A Monte Carlo reference-based consensus clustering algorithm

M3C improves consensus clustering by simulating null distributions to reduce bias and false positives in determining the number of clusters.

Spectrum: Fast density-aware spectral clustering for single and multi-omic data

Spectrum improves clustering speed and performance for single and multi-omic data by using a density-aware kernel and tensor product graph integration.