Alexander Stumpf

This study shows that autoantibodies against GABAB receptors cause presynaptic pathology leading to cognitive decline and memory impairment.

This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.

The paper investigates the role of Calbindin-containing CA1 pyramidal cells in cognitive flexibility during spatial tasks in mice, finding they support adaptation to environmental changes.

This study investigates the role of synapsin isoforms in presynaptic plasticity at hippocampal mossy fiber boutons in male mice, finding decreased short-term and increased long-term plasticity upon synapsin deletion.

The paper identifies primate-specific CAMK2B splice variants regulated by branch point weakening, showing their role in long-term potentiation and learning.

The paper investigates how serotonin modulates slow oscillations in the entorhinal cortex and identifies somatostatin interneurons activated by 5-HT2A receptor as key suppressors of these oscillations in anesthetized mice.

This paper introduces a CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency that mirrors human phenotypes, including cognitive impairments and epilepsy, and identifies synaptic transmission deficits.

This study shows that neuronal autophagy regulates axonal ER calcium stores to control neurotransmission and postnatal viability in mice.

The paper introduces synaptoPAC, an optogenetic tool that induces presynaptic plasticity by increasing transmitter release at specific brain synapses.

This study shows RIM-BP2 has different roles in neurotransmitter release at hippocampal mossy fiber and pyramidal CA3-CA1 synapses, with RIM-BP2 promoting vesicle docking/priming at mossy fibers by recruiting Munc13-1.