Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology
Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes S. Gnörich, Todd Logan, Steffanie Heindl, Miriam Annika Vogt, Endy Weidinger, Lina Riedl, Karin Wind-Mark, Artem Zatcepin, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, , Christian Haass
This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.
bioRxiv · Jul 8, 2021 · PreprintNeuroscience