Gernot Kleinberger

This study investigates the association between Klotho heterozygosity and Alzheimer's disease risk in APOE4 carriers using multiple AD endophenotypes from large cohorts.

This study shows that chronic PPARγ agonist treatment increases amyloid-beta fibrillarity but improves cognition and synaptic density in mouse models.

This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.

This study identifies TDP-25 inclusions as sequestering proteasomes, leading to proteostasis impairment in ALS/FTD.

This study shows that pre-therapeutic microglia activation and sex predict the response to chronic immunomodulation in AD mouse models using TSPO-PET.

This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.